[Site News] On December 5th, the team of Professor Chen Zijiang of Shandong University Reproductive Medicine and the team of Professor Liu Jiang of the Beijing Institute of Genomics of the Chinese Academy of Sciences once again cooperated and published an article titled "Article" in the journal Nature . Key role for CTCF in establishing chromatin structure in human embryos ". This result revealed for the first time the dynamic changes in the three-dimensional structure of chromatin in early human embryos, and found that CTCF protein has an important regulatory role in the topological domain (TAD) in early embryo development.
If human DNA is drawn into a straight line about 2 meters long, the diameter of the nucleus is only 5 micrometers to 10 micrometers. Recent studies have found that DNA can form different topological domains by orderly folding, and eventually form advanced chromatin. structure. Advanced chromatin structure is an important epigenetic factor, which is closely related to the regulation of gene expression. Abnormal chromatin structure can cause a series of problems such as finger malformation, gender reversal, and cancer occurrence. However, the dynamic changes of chromatin structure in gamete and embryo development have been an unsolved mystery. Therefore, exploring the dynamic changes and mechanisms of the three-dimensional structure of chromatin in human sperm and early embryos is of great significance for deep understanding of human embryonic development.
The study for the first time analyzed the advanced structures of human sperm and early embryos, and found that during the early development of human embryos, genome-wide chromatin advanced reprogramming appeared, and that the CTCF protein played a vital role in this process. In addition, it is also found that human sperm lack TAD structure, which is completely different from sperm of other species (including mice, macaques, etc.). This study, for the first time, mapped the three-dimensional conformational map of human early embryonic chromatin, which has important theoretical and clinical significance for deep understanding of early human embryonic development, and is a major breakthrough in the field of reproductive development.
Related links : http://www.nature.com/articles/s41586-019-1812-0
[Contributed by: Alexander reproductive Author: Wang Jianfeng Editor: News Studio Editor: Zhang Dandan]
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